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![]() ![]() So, my question is really if you heard of any specific issues in installing various bioinformatics tools on Big Sur. In any case, I wouldn't like to solve java installation issues for instance by upgrading to Big Sur and not be able to install instead others bioinformatics tools. Might be easier to install on Big Sur? Besides, I also get the message that macOS HS is not supported by mac anymore, which in time might become a problem. I get Error: A JNI error has occurred, please check your installation and try again Now I have problems installing java for GATK4 installation. However, it was a headache to install for instance MySQL (not bioinformatics related) on HS, and I understood that it would have been much easier to do this on Catalina and I assume Big Sur as well. 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